- - European weblog on food, health and environment
The 21st century - time to wake
up .
Cancer to be the leading cause of death in
2010 through deadly cocktail of toxins ? We destroy our lungs with cigarettes, feed our
kids fast sugars. trans fats, salt, artificial flavors and colors, chemical sugars,
vaccines, etc. Then we wonder how it is that an increasing percentage of the population
develops chronic diseases such as asthma, allergies, diabetes, cancer, food intolerances,
skin problems and bowel problems. Mercury in fish and thermometers poses a problem for
most, but in tooth fillings or flu shots it doesn't seem to be a problem. Where's the
logic in that? We have the same ambivalence about antibiotics, the 'wonder drug' for
bacterial infections but also the great killer of your intestinal flora. Never mind that
friendly gut bacteria play a crucial role in maintaining long-term health. According to
ancient Chinese wisdom death resides in the bowels.
Video - T. Boone Pickens: Longer
Explanation of His Plan
T. Boone Pickens gives an extended account
of his plan to break America's dependency on foreign oil. With a combination of domestic
natural gas and renewable alternative, Pickens offers an action plan to save America's
energy future.
It's a known fact that using microwave to
heat up food has negative effects on the human body. Listen to Dr. Group explain the
dangers of using microwaves to heat up your food.
Video - Politicians vote to avoid
the promised referendum on the EU
Dishonesty and avoidance tactics from some
familiar faces, and some unfamiliar faces, as the puppet representatives of the REAL
government conspire to abolish British national sovereignty and to prevent the referendum
that was promised to the British people. The Lisbon Treaty was always a "must
be" - a necessary step in the long-term plans of the architects of this new world
order.
Researchers generate hydrogen
without the carbon footprint
A greener, less expensive method to produce hydrogen for fuel may eventually be possible
with the help of water, solar energy and nanotube diodes that use the entire spectrum of
the sun's energy, according to Penn State researchers.
Possible link found between X-rays
and prostate cancer
Researchers at the University of Nottingham have shown an association between certain past
diagnostic radiation procedures and an increased risk of young-onset prostate cancer -- a
rare form of prostate cancer which affects about 10 percent of all men diagnosed with the
disease.
TG2 identified as potential
therapeutic target in chemo-resistant ovarian cancer
M. D. Anderson researchers connect overexpression of tissue type transglutaminase with
poor prognosis in ovarian cancer, identify the relevant pathway, and shut TG2 down with an
siRNA liposomal nanoparticle. They previously pinpointed TG2's role in resistant and
metastatic melanoma and breast and pancreatic cancers. This crucial protein fuels
different cancers through different pathways.
Consumption of nut products during
pregnancy linked to increased asthma in children
Expectant mothers who eat nuts or nut products like peanut butter daily during pregnancy
increase their children's risk of developing asthma by more than 50 percent over women who
rarely or never consume nut products during pregnancy, according to new research from the
Netherlands.
Stomach bug appears to protect kids
from asthma, says NYU study
A long-time microbial inhabitant of the human stomach may protect children from developing
asthma, according to a new study among more than 7,000 subjects led by NYU Langone Medical
Center researchers. Helicobacter pylori, a bacterium that has co-existed with humans for
at least 50,000 years, may lead to peptic ulcers and stomach cancer. Yet, kids between the
ages of 3 and 13 are nearly 59 percent less likely to have asthma if they carry the bug,
the researchers report.
Brain cancer study - Magnitude of
post-vaccine immune response linked to clinical outcomes
Researchers conducting a clinical trial of a dendritic cell vaccine designed to fight
malignant brain tumors called glioblastoma multiforme have found a correlation between the
"intensity" of a patient's immune response and clinical outcome, according to an
article in the July 15 issue of the journal Cancer Research.
Researchers link Huntington's
disease to overactive immune response in the brain
The damage to brain tissue seen in Huntington's disease may be caused by an overactive
immune response in the bloodstream and the brain, according to new findings from two teams
of researchers at the University of Washington in Seattle and University College London.
The findings will be published online July 14 in the Journal of Experimental Medicine.
Farming at Young Age May Lead to
Bone Disease in Adulthood
CincinnatiAlthough farm chores are likely to keep young boys in shape and out of
trouble, University of Cincinnati (UC) environmental health experts caution that it could
be harmful to overall bone health if done too often at a young age.
New study sheds light on how
intracellular pathogens trigger the immune system
A new study led by UC Berkeley biologists has identified a molecular alarm system in which
intracellular pathogens send out signals that kick the immune response into gear. The
findings shed light on how host cells recognize and destroy the pathogenic bugs living
within their walls, and may even provide new targets for the research and development of
new vaccines and drugs.
'Snapshots' of eyes could serve as
early warning of diabetes
A new vision screening device, already shown to give an early warning of eye disease,
could give doctors and patients a head start on treating diabetes and its vision
complications, a new study shows. It captures images of the eye to detect metabolic stress
and tissue damage that occur before the first symptoms of disease are evident.
More kidney stone disease projected
due to global warming, researchers predict
Global warming is likely to increase the proportion of the population affected by kidney
stones by expanding the higher-risk region known as the kidney-stone belt into
neighboring states, researchers at UT Southwestern Medical Center and UT Dallas have
found.Dehydration is one of the risk factors linked to kidney-stone disease, and the paper
suggests global warming will exacerbate this effect. The researchers predict that by 2050,
higher temperatures will cause an additional 1.6 million to 2.2 million kidney-stone
cases, representing up to a 30 percent growth in some areas.
Allergic diseases appear more often in children who grow up near busy roads. This is the
result of a study of several thousand children, now published in the American Journal of
Respiratory and Critical Care Medicine.
A cohort study of in utero
polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
Polychlorinated biphenyls (PCBs) are ubiquitous industrial chemicals that persist in the
environment and in human fatty tissue. PCBs are related to a class of compounds known as
dioxins, specifically 2,3,7,8-TCDD (tetrachloro-dibenzodioxin), which has been implicated
as a cause of altered sex ratio, especially in relation to paternal exposures.
89% of childrens food
products provide poor nutritional quality, but 62% of them still make health claims
Nine out of ten regular food items aimed specifically at children have a poor nutritional
content because of high levels of sugar, fat or sodium - according to a detailed
study of 367 products published in the July issue of the UK-based journal Obesity Reviews.
Just under 70 per cent of the products studied - which specifically excluded
confectionery, soft drinks and bakery items - derived a high proportion of calories from
sugar. Approximately one in five (23 per cent) had high fat levels and 17 per cent had
high sodium levels. Despite this, 62 per cent of the foods with poor nutritional quality
(PNQ) made positive claims about their nutritional value on the front of the packet.
Arginine is een aminozuur en daarmee een belangrijke bouwsteen van eiwitten in het
lichaam. Arginine helpt onder andere het bij de afweer tegen infecties, bevordert de
wondgenezing en tevens is het de voorloper van het zogenaamde stikstofmonoxide (NO). NO
zorgt voor een goede doorbloeding van de organen met name tijdens perioden van stress,
zoals rond operaties en bij infectie. Het lichaam maakt echter ook een stof die de
belangrijke omzetting van arginine in NO tegengaat, het asymmetrisch dimethylarginine
(ADMA).
Insulineresistentie is een vorm van suikerziekte welke voorkomt na operaties door de
invloed van het trauma en eventueel langdurig vasten voor de operatie. Deze
insulineresistentie geeft een verhoogde kans op infectieuze complicaties maar is tevens
gerelateerd aan tumorgroei. Door voor de operatie patiënten een koolhydraatrijke drank te
geven, is het mogelijk deze resistentie na de operatie te verminderen.
Asymmetrisch dimethylarginine (ADMA) is een endogene remmer van het enzym
stikstofmonoxidesynthase dat het aminozuur arginine omzet in stikstofmonoxide.
Stikstofmonoxide is de belangrijkste vasodilatator en is ten tijde van stress van groot
belang om organen zoals de lever, de nier en de darm beter te perfunderen. Indien de ADMA
spiegels in het plasma en/of het weefsel verhoogd zijn, oefent ADMA een negatieve invloed
uit op zowel het cardiovasculaire systeem alsmede op het immuunsysteem, omdat
stikstofmonoxide in deze orgaansystemen een belangrijke rol speelt. Ernstig zieke
patiënten hebben een verhoogd catabolisme met soms een verminderde functie van lever en
nier. Er vindt dus een verhoogde productie en tevens een verminderde eliminatie van ADMA
plaats. Wij hebben bij ernstig zieke patiënten op de intensive care afdeling (IC)
aangetoond dat de plasma concentratie van ADMA verhoogd is en dat de ADMA concentratie bij
deze patiënten onafhankelijk gerelateerd is aan de aanwezigheid van leverfalen, alsmede
aan de concentraties van lactaat en bilirubine als parameters voor leverfunctie.
Al honderden jaren lang wordt Temoe Lawak toegepast, én met succes. Vanwege de gele kleur
(de curcuminen) werd het veel gebruikt bij geelzucht, maar ook omdat de wortelstokken heel
erg leken op de vorm van de galblaas. Temoe Lawak is een fraai voorbeeld van een
geneesmiddel uit de signatuurleer en wel in de dubbele zin van vorm en kleur. Het gebruik
van curcumasoorten gaat ver terug in de geschiedenis. In het Oude Testament al wordt
curcuma vermeld en ook Marco Polo heeft het onder ogen gehad. In de 18e eeuw is curcuma al
opgenomen in een aantal farmaceutische handboeken. Rond 1900 komt de plant Curcuma
Xanthorrhiza als Temoe Lawak via de Hollanders op de Europese markt.
Calcium may be the key to
understanding Alzheimer's disease
Researchers at the University of Pennsylvania School of Medicine have shown that mutations
in two proteins associated with familial Alzheimer's disease disrupt the flow of calcium
ions within neurons. The two proteins, called PS1 and PS2 (presenilin 1 and 2), interact
with a calcium release channel in an intracellular cell compartment.
The olives reputation as a health food is being borne out by modern science, as
studies of olive-consuming Mediterranean peoples have shown. To keep the worlds
olive lovers satisfied, an intensive wave of olive planting has occurred in the past
decade in many parts of the world. Traditionally, olives have been cultivated in the
Mediterranean region. But fresh water is becoming increasingly hard to come by in semiarid
areas, and irrigation of most new olive plantations is often accomplished with low-quality
sources of water that contain relatively high levels of salt.
Too much, too little sleep
increases ischemic risk in postmenopausal women
Sleeping nine hours or more a night significantly increases the risk for ischemic stroke
among post menopausal women. Sleeping less than 6 hours showed a modest increase risk of
stroke, but was reported by twice as many women. The findings cannot be applied to other
groups.
As rates rise, researchers find
better way to identify melanoma
University of Rochester Medical Center researchers found a new protein produced
excessively in malignant melanoma, a discovery that is particularly relevant as skin
cancer rates climb dramatically among young women.
Quick Formula Could Forecast Which
Cancers Chemo Could Kill
Researchers at the University of Rochester Medical Center have coined a simple formula
that predicts how well a certain chemotherapy will work for targeting brain and other
nervous system cancers. The formula, which will publish in mid-July in Cancer Chemotherapy
and Pharmacology, is pegged to two important proteins that compose such hard-to-kill
tumors one of which, ironically, makes them so drug-resistant in the first place.
UNC, Caltech research finds further
evidence for genetic contribution to autism
This manifests as a tendency not to prefer interactions with others, not to enjoy
small talk for the sake of the social experience and to have few close
friendships involving sharing and mutual support, said Piven, senior author of the
study, Sarah Graham Kenan professor of psychiatry in the UNC School of Medicine and
director of the newly established Carolina Institute for Developmental Disabilities.
This characteristic is really a variation of normal and not associated with any
functional impairment.
Could arthritis wonder drugs
provide clues for all disease?
Drugs that have helped treat millions of rheumatoid arthritis sufferers may hold the key
to many more medical conditions, including atherosclerosis a leading cause of heart
disease says the researcher who jointly invented and developed them. Professor Marc
Feldmann will tell scientists attending the 2008 Congress of European Pharmacological
Societies (EPHAR) hosted by the British Pharmacological Society that drugs
he and colleagues helped develop have already proved successful against other autoimmune
diseases. The drugs target proteins called cytokines, which are protein messaging
molecules released by immune cells to alert the immune and other systems that the body is
under attack from a pathogen and to initiate a protective counter-response against the
infection. "In autoimmune diseases, such as arthritis, we discovered that cytokines
are over-produced causing the immune system to fight itself, resulting in inflammation and
tissue destruction," said Professor Feldmann, from Imperial College London, who is
speaking at the EPHAR 2008 conference at The University of Manchester this week. "We
further found that by blocking just one cytokine Tumor Necrosis Factor (TNF) alpha
we were able to block all the cytokines involved in the inflammation, with
remarkable clinical results."
Researchers find a partially shared
genetic profile between schizophrenia and bipolar disorder
Both schizophrenia and bipolar disorder can be disabling conditions, and both present
clinically with significant mood and psychotic symptoms. These two illnesses also share
genetic variants that might be involved in the predisposition to both disorders. A new
study scheduled for publication in the July 15th issue of Biological Psychiatry sought to
analyze the patterns of gene expression in the brains of individuals diagnosed with one of
these disorders to search for a common "characteristic [genetic] signature."
Singapore Researchers Identify
Virulence Factor That Induces Fatal Fungal Infection
Scientists here have found that certain substances from bacteria living in the human
intestine cause the normally harmless Candida albicans fungus to become highly infectious.
This discovery by researchers from the Agency for Science, Technology and Research
(A*STAR)s Institute of Molecular and Cell Biology (IMCB) could possibly lead to the
development of novel treatments for immunocompromised patients infected by the fungus.The
team of scientists, led by Associate Professor (A/P) Wang Yue, a principal investigator at
the IMCB, has identified peptidoglycan (PGN) a carbohydrate from bacteria as
a factor responsible for causing the conversion of the otherwise harmless C. albicans to
its infectious form. Once in this form, the fungus is able to invade surrounding tissues
and escape destruction by the bodys own immune cells. As immunocompromised patients
such as those with AIDS or those undergoing chemotherapy or radiation treatment are
extremely susceptible to fungal-induced systemic infections, this finding offers an
important clue to the basis of C. albicans infections.
Early study reveals promising
Alzheimer's disease treatment
A drug once approved as an antihistamine in Russia improved thinking processes and the
ability to function in patients with Alzheimer's disease in a study conducted there, said
an expert at Baylor College of Medicine in Houston. The findings are published in the
current issue of the journal The Lancet.
Discovery of a new signaling
mechanism may lead to novel anti-inflammatory therapy
A team of researchers at the University of California, San Diego School of Medicine has
uncovered a new signaling mechanism used to activate protein kinases that are critical for
the body's inflammatory response.
The protein CAR is essential for
normal heart function
The adhesion protein CAR is expressed in a region of the adult heart known as the
intercalated disc (which supports synchronized contraction of the heart), but its function
there is unknown. However, a new study, by Kirk Knowlton and colleagues, at the University
of California, San Diego, has revealed that CAR is essential for normal heart function in
mice. In the study, adult mice lacking CAR in the heart exhibited a complete block in
conduction of electrical impulses from the upper chambers of the heart (the atria) to the
lower chambers (the ventricles) (a process known as atrioventricular [AV] conduction),
meaning that the heart did not beat synchronously. The complete block in AV conduction
occurred for varying lengths of time in the different mice analyzed. Furthermore, the mice
developed heart disease by 21 weeks of age, and this was associated with disorganization
of the intercalated disc structure. Detailed analysis indicated that in the absence of CAR
in the heart, cell-cell junctions at both the site of AV conduction and the intercalated
disc were abnormal. The authors therefore conclude that CAR is essential for the adult
mouse heart to function normally and suggest that these results have implications for the
development of therapeutics for genetic and acquired heart diseases.
Researchers discover primary sensor
that detects stomach viruses
Scientists at Washington University School of Medicine in St. Louis have identified the
primary immune sensor that detects the presence of stomach viruses in the body. They show
that the sensor -- a protein called MDA-5 -- triggers an immune response that revs up the
body's defenses to fight off the infection. This knowledge may help develop a treatment
that prevents or reduces infection, the researchers suggest in their study, published July
18 in the open-access journal PLoS Pathogens.
How cells die determines whether
immune system mounts response
Every moment we live, cells in our bodies are dying. One type of cell death activates an
immune response while another type doesn't. Now researchers at Washington University
School of Medicine in St. Louis and St. Jude's Children's Research Hospital in Memphis
have figured out how some dying cells signal the immune system. They say the finding
eventually could have important implications in the treatment of autoimmune diseases and
cancer.
Suckling infants trigger surges of
trust hormone in mothers' brains
Researchers from the University of Warwick, in collaboration with other universities and
institutes in Edinburgh, France and Italy, have for the first time been able to show
exactly how, when a baby suckles at a mother's breast, it starts a chain of events that
leads to surges of the "trust" hormone oxytocin being released in their mothers'
brains. The study, published on 18th July in the journal PLoS Computational Biology,
focuses on the role of oxytocin, a very important hormone recently found be involved in
the enhancement of "trust" and love in humans and animals. Oxytocin has long
been known to be the trigger that, when released into the blood, causes milk to be let
down from the mammary gland. When oxytocin is released within the brain, it also helps to
strengthen the bond between mother and child, but to have these effects, a very large
amount must be released abruptly to cause a wave of the hormone that can spread through
the brain. What was not known before this study is exactly how the few thousand neurones,
which are specialized to release oxytocin, are marshalled together to produce a
sufficiently intense burst of activity to do all of that. In fact, even when a child is
not suckling these neurons are continually producing oxytocin but in small amounts and in
a much more uncoordinated way. Previous studies on individual neurons have found no
obvious way of modifying their behaviour to get the coordinated response needed to produce
the large, regular pulses of oxytocin that are needed. Now this University of Warwick led
team of experimental neuroscientists and theoreticians have found a likely answer. The
neuroscientists have found that in response to suckling the neurons start releasing
oxytocin from their "dendrites" as well as from their nerve endings - this was
unexpected because dendrites are usually thought as the part of a neurone which receive,
rather than transmit information.
Protein transports nutrients
believed to protect against eye disease
Scientists have identified the protein responsible for transporting nutrients to the eye
that are believed to protect against the development of age-related macular degeneration,
a leading cause of vision loss in elderly Americans. The research sought to illuminate the
process by which compounds called lutein and zeaxanthin move from the bloodstream to the
eye.
New Approach Sheds Light on Ways
Circadian Disruption Affects Human Health
Growing evidence indicates that exposure to irregular patterns of light and darkness can
cause the human circadian system to fall out of synchrony with the 24-hour solar day,
negatively affecting human health but scientists have been unable to effectively
study the relationship between circadian disruptions and human maladies.
Scientists at Georgia Tech have developed a potential new treatment against cancer that
attaches magnetic nanoparticles to cancer cells, allowing them to be captured and carried
out of the body. The treatment, which has been tested in the laboratory and will now be
looked at in survival studies, is detailed online in the Journal of the American Chemical
Society.
Researchers Discover Link between
Organ Transplantation and Increased Cancer Risk
Researchers have determined a novel mechanism through which organ transplantation often
leads to cancer, and their findings suggest that targeted therapies may reduce or prevent
that risk. In the July 15, 2008, issue of Cancer Research, researchers at Harvard Medical
School found in animal and laboratory experiments that the anti-rejection,
immunosuppressive drug cyclosporine ramps up expression of vascular endothelial growth
factor (VEGF), which signals the growth of new blood vessels that can feed tumors. They
also found that simultaneously administering an anti-VEGF therapy with cyclosporine in
mice repressed this tumor growth. Several inhibitors of VEGF are already in use in human
cancer therapy.
Weizmann Institute scientists' new
technique gets to the root of cancer
In two complementary studies, Weizmann Institute scientists have developed a new method
for reconstructing a cell's 'family tree,' and have applied this technique to trace the
history of the development of cancer. So far, the scientists have been able to calculate
the age of the tumor and characterize its growth pattern. The scientists believe cell
lineage studies of cancer can eventually lead us to the root of cancer.
Tobacco industry manipulated
cigarette menthol content to recruit new smokers among young people
Researchers at Harvard School of Public Health explored tobacco industry manipulation of
menthol levels in specific brands and found a deliberate strategy to recruit and addict
young smokers by adjusting menthol to create a milder experience for the first time
smoker.
Vitamin A pushes breast cancer to
form blood vessel cells
Researchers at Georgetown University Medical Center have discovered that vitamin A, when
applied to breast cancer cells, turns on genes that can push stem cells embedded in a
tumor to morph into endothelial cells. These cells can then build blood vessels to link up
to the body's blood supply, promoting further tumor growth. They say their findings,
published in the July 16 online issue of PLoS ONE, is a proof of principle of the new
and controversial "vasculogenic mimicry" theory, proposing that,
as needed, tumors build their own blood pipelines. This is very different from the
well-accepted role of tumor angiogenesis, when tumors send signals to blood vessels to
grow toward the cancer. The study's senior author, Stephen W. Byers, Ph.D., a professor of
oncology and cell biology at Georgetown's Lombardi Comprehensive Cancer Center, also says
that this study helps explain why retinoids-- natural or synthetic vitamin A agents--have
had mixed results in treating cancer. "Finding that vitamin A may cause some breast
cancer cells to form blood vessels brings up the rather disturbing notion that treatment
with these drugs may actually stimulate tumor growth," says Byers.
Researchers Discover Paradox About
General Anesthesia - It Can Increase Post-Surgical Pain
The general anesthesia that puts patients into unconscious sleep so they do not feel
surgical pain can increase the discomfort they feel once they wake up, say researchers
from Georgetown University Medical Center. They say their findings, the first to
scientifically explain what has been anecdotally observed in the clinic, may lead to wider
use of the few anesthetics that dont have this side effect, or to the development of
new ones. In the June 23rd issue of the Proceedings of the National Academy of Sciences
(PNAS), the scientists report that noxious anesthesia drugs - which most of
these general anesthetics are - activate and then sensitize specific receptors on neurons
in the peripheral nervous system. These are the sensory nerves in the inflammation and
pain pathway that are not affected by general anesthesia drugs that target the central
nervous system the brain and the spinal cord.
UCLA study identifies mechanism
behind mind-body connection
Immune cells end in protective caps called telomeres that are shorter in the elderly --
and in persons suffering chronic stress. A new UCLA study suggests that the hormone
cortisol is the culprit behind telomeres' early aging in stressed-out people and offers a
potential drug target for protecting the immune system against the damage caused by
long-term stress.
Scientists demonstrate means of
reducing Alzheimer's-like plaques in fly brain
Neuroscientists at Cold Spring Harbor Laboratory are part of a collaboration that has
succeeded in demonstrating that overexpression of an enzyme in the brain can reduce
telltale deposits causally linked with Alzheimer's disease.
Impact of mechanical stimulation on
the initiation of colon cancer
Inappropriate activity of the beta-catenin transcriptional factor, most often due to
truncating mutations in the adenomatous polyposis coli (APC) gene, is known to be the
principal cause of colon cancer development, yet loss of APC appears to be necessary but
not sufficient in itself to trigger neoplastic transformation. Environmental signals, in
addition to loss of both APC alleles, were suggested to be required for both initiation of
tumourigenesis and for tumour progression. Understanding the source of these additional
environmental cues which promote tumour initiation and progression will allow the
development of alternative approaches to colon cancer prevention and treatment. Because
the gastrointestinal tract is naturally submitted to significant endogenous mechanical
strains, Emmanuel Farge and his colleagues at the Curie Institute in Paris have tested the
ability of colon explants from normal or APC-deficient mice to respond to mechanical
strain by analyzing changes in the distribution of beta-catenin and expression of its
target genes and report on their findings in the HFSP Journal.
Anthracyclines is a type of chemotherapeutic drug that has been used in the treatment of
various forms of cancer, including acute myeloid leukaemia (AML), for decades. Still, it
is not known exactly how the anthracyclines put cancer cells out of action, nor do we know
why some patients eventually become resistant to this chemotherapy. A group of researchers
at the departments of biomedicine and medicine has looked into the matter.
Does your sunscreen work? An investigation of nearly 1,000 brand-name sunscreen products
finds that 4 out of 5 contain chemicals that may pose health hazards or don't adequately
protect skin from the sun's damaging rays. Some of the worst offenders are leading brands
like Coppertone, Banana Boat, and Neutrogena.More than a million cases of skin cancer are
diagnosed in the U.S. every year, but FDA still hasn't finalized sunscreen standards first
announced 30 years ago. Meanwhile, companies are free to claim but not provide broad
spectrum protection. Until FDA requires that all sunscreens be safe and effective,
Environmental Working Group's comprehensive sunscreenguideincluding a list of 143
products that offer very good sun protectionfills in the gaps.
Weight Loss with a
Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Mediterranean and low-carbohydrate diets may be effective alternatives to low-fat diets.
The more favorable effects on lipids (with the low-carbohydrate diet) and on glycemic
control (with the Mediterranean diet) suggest that personal preferences and metabolic
considerations might inform individualized tailoring of dietary interventions.